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However, the half-life in the bloodstream is extremely short, so for optimal effects, very frequent administration is needed, and the efficacy is unproven

Mller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn P-H (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

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This study hypothesizes that significant decreases in three key indicatorsrespiratory quotient, heart rate, and subjective perception of exertion would indicate that the experimental L-carnitine (LC) supplementation protocol reduces exercise load and enhances endurance limits more effectively than the classical supplementation strategy