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This phenomenon can be so marked with certain G6PD variants that patients in the posthemolytic state are found to be relatively resistant to further challenge

Conversely, the ubiquitin ligase E3 HUWE1/MULE, which acts as a negative regulator of ferroptosis, regulates iron metabolism by targeting transferrin receptor 1 and counteracts abnormal iron accumulation, thereby alleviating acute liver injury caused by hepatic ischemia-reperfusion (I/R) [34]

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It has a role in creatine synthesis which is a nutrient found primarily in muscle tissue