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Delgado JCL

Dickkopf 1 (DKK1) regulates SHMT2 transcription through the AKT-Sp1 (Specificity Protein 1) signaling axis, modulates redox homeostasis and mitochondrial function, and exerts anti-apoptotic and proliferative effects on human PAECs (hPAECs), thus playing a positive role in vascular remodeling related to pulmonary hypertension (PH) [143]