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183 A mitochondria-targeting antioxidant can reduce the production of neutrophil mtROS and result in a decrease in NETosis

Accordingly, high mTORC1 activity in cancer cells promotes aerobic glycolysis and drives glucose addiction 162,163 (Fig

The dysregulated lipid metabolism creates a lipotoxic environment which promotes the development of NAFLD, especially the progression from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH)