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Description

Under extreme pressure from extracellular cysteine scarcity, cells exhibit complex compensatory logic

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Xue L, Yu D, Wang L, Sun J, Song Y, Jia Y, et al

doi: 10.1038/s41586-023-06511-9 15 KhanANHEmmonsTRWongJTAlqassimESingelKLMarkJet al

Structurally, AARS1/2 share a class II aminoacyl-synthetase fold with an alanine-binding pocket shaped by key specificity residues (AARS1: M46, R77, N216, D239, G241