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It is, therefore, possible that redox thresholds in B cells are subset-specific, and that these thresholds mediate homeostatic functions that could account for the differing properties of MZB and FoB

P.KumarA.DwivediS.DeebaF.KumarS.et al (2015a)

The human evidence is limited, but the mechanistic rationale is enough that this remains an active research area

People with histamine intolerance usually have several of the symptoms above, but likely wont have all of the symptoms.[ref] Genetics plays a big role in histamine intolerance

Too much histamine there can be detrimental, and people with chronic heart failure have higher average plasma histamine levels