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Peroxisome proliferator-activated receptor gamma (PPAR) agonists inhibit Th17-cell production by eliminating GLS1, reducing the levels of the downstream metabolite of -KG, 2-HG, and downregulating the levels of the activating histone marker of H3K4 methylation (H3K4me3) in the promoter and CNS2 regions of the IL-17 gene ( Figure 2 ) (51, 52)

However, the greatest damage that is done by H 2 O 2 derives from its ability to form hydroxyl radical OH, the most pernicious and reactive of the ROS species

Chnh v vy Glutathione c tc dng bo v c th chng li qu trnh oxy ha t bo, gim stress oxy ha, ngn chn nhng yu t gy hi t bo, gy c t bo nh cc gc t do (ROS)

Raw data files from LC-MS/MS data were processed using Proteome Discoverer v2.1 (Thermo Scientific), and then searched against a human protein database (UniProtKB, reviewed) using the Mascot search engine programme (Matrix Science, UK)

La secuencia Ala-Glu-Asp-Gly fue identificada como la secuencia activa mnima el fragmento ms corto que retena las propiedades activadoras de telomerasa, reguladoras neuroendocrinas y promotoras de longevidad del extracto de polipptido completo