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These structural data reveal a binding mode largely consistent with native amylin, but with notable differences: cagrilintide anchors via the F23 residue and forms a distinctive E14R17 intramolecular salt bridge that stabilizes its receptor-bound conformation

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Acknowledgements This work was supported by grants from MIUR (FIST 2003 and FIRB RBNE0155LB-03) to G.T.

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