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In the obesity group, there was a significant and clinically meaningful reduction in body weight of 4.74% at week 8, with weight continuously decreasing during the 8-week treatment period

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4.4 Obesity-induced gut microbiota dysbiosis and OS Through extensive studies, it has been demonstrated that obesity markedly changes the composition of microbiota (39), characterized by decreased diversity of microbiota compared with that in normal-weight individuals (40)

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That said, the animal research is genuinely interesting and points toward several areas worth continued investigation