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However, some studies have shown that the rate of decline in renal function slows down with age, suggesting that other factors are at play, particularly the increased risk of death and the differences in underlying causes of chronic kidney disease among elderly patients ( FIGURE 3 4.1 Acute kidney injury The incidence of chronic diseases such as hypertension, diabetes, atherosclerosis, and heart failure tend to rise with advancing age, which subsequently leads to the phenomenon of polypharmacy among the elderly population