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Agmatine protects against intracerebroventricular streptozotocin-induced water maze memory deficit, hippocampal apoptosis and Akt/GSK3 signaling disruption

Actinomyces (121, 122), Prevotella (123), Bacteroides (120, 124), EscherichiaShigella (125) are the main species increased, whereas Mycobacterium , Lactobacillus , Enterobacter (123), Deltaproteobacteria , and Clostridiaceae decreased (126), including CB , FP , Clostridium leptum , Clostridium cluster XlVa , Clostridium cluster XlVb , Clostridium cluster XVIII (127)

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Male SD rats were administered a single IM injection of blank solvent (excipient), and biological samples, including whole blood, plasma, urine, feces, and tissues, were collected for background control