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Dihexa has a long half-life (approximately 12 days), so effects are cumulative and build over time

Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min

The fact is that the frequency of one injection every three months means that the quality of life for many patients is considerably compromised by gross under treatment

Even after age differences were accounted for, the effect on memory remained