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Upregulation of Bcl-2 Confers Resistance to FLT3 Inhibition in FLT3-ITD AML with Secondary Acquired Mutations

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Furthermore, the optimization of ferroptosis inducer delivery through advanced nanomedicine approaches, such as engineered nanocarriers, tumor-targeted exosomes, or BBB-penetrating delivery systems, could significantly enhance therapeutic efficacy while minimizing systemic toxicity and off-target effects