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The mild OS may activate the bladder afferent nerves (188) and stimulate the detrusor muscle cells directly (195), leading to bladder hyperactivity, while severe or prolonged OS can induce detrimental alterations in nerves and the detrusor muscle ultimately resulting in detrusor underactivity (196)

This can be prevented by long-term exercise by obtaining cellular adaptation (Neubauer et al., 2008

anaphylaxis to injectable thiamine, while extremely uncommon, has been reported

The Xth Epilepsy nternational Symposium , New York: Raven Press

Scientists have also learned how to develop synthetic peptides (lab made versions), which have been designed to mimic or enhance these natural functions in the body