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It plays a crucial role in metabolic processes like the Krebs cycle and oxidative phosphorylation

Patient and sample attributes for the TCGA cohort were downloaded from the GDC data portal (gdc-tcga-phs000178-controlled) using the R package GenomicDataCommons version 1.18.0 and from the supplementary tables publicly available on the PanCanAtlas page ( Only patients included in the BRCA study of TCGA and for which we found no reason for exclusion were considered (Supplementary Fig

Again, this is theoretical rather than documented, but merits consideration for high-risk individuals

Reunanen, J

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