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Neither is simply worse theyre serious in different ways: rheumatoid arthritis is potentially more dangerous because it is systemic and can damage organs and shorten life expectancy if untreated, while osteoarthritis is usually localized but is the leading cause of joint disability worldwide

Many clients pair vitamin C with zinc for enhanced immune support, B vitamins for energy, glutathione for antioxidant protection, or NAD+ for cellular optimization

Statements Author contributions LY: Conceptualization, Formal Analysis, Investigation, Methodology, Writing original draft, Writing review and editing

doi: 10.1146/annurev-pharmtox-011112-140320 207

Although the insolubility of bilirubin and its susceptibility to oxidation complicate its use as a therapeutic molecule, research is continuing