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How Might BPC-157 Influence Healing

Switch of NAD salvage to de novo biosynthesis sustains SIRT1-RelB-dependent inflammatory tolerance

10.1016/j.celrep.2015.04.031 45 Dall'AcquaS.GrabnarI.VerardoR.KlaricE.MarchionniL.Luidy-ImadaE.et al (2019)

The group receiving a 0.3 mg dose experienced a 6.0% weight loss, with 0.6 mg there was a 6.8% weight loss, with 1.2 mg there was a 9.1% weight loss, with 2.4 mg there was a 9.7% weight loss, and weigh 4.5 mg there was a 10.8% weight loss, compared with 3.0% weight loss for pooled placebo

By blocking NNMT, 5-amino-1MQ promotes an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor essential for cellular metabolism