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By the time most people reach their 60s, their natural GHK-Cu is a fraction of what it was in their 20s

When to reduce dose or stop Reduce your dose if side effects are persistent (lasting more than a few days), interfere with daily activities, or worsen rather than improve over time

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However, research performed by doctors explains that when people can properly absorb and store vitamin B12, it is stored within the body for between 3 to 5 years

Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency