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Liver lesions in rats associated with wrapping of the torso

Mechanistically, DOX stabilizes the copper importer SLC31A1 (CTR1) by inhibiting its proteasomal degradation and downregulating the copper efflux transporter ATPase Copper Transporting Beta (ATP7B), leading to a net increase in cellular copper [17, 76]

van Zonneveld, P

Abstract: Zeevalk, G

Scientific Opinion on the substantiation of health claims related to riboflavin (vitamin B2) and contribution to normal energy-yielding metabolism (ID 29,35,36,42), maintenance of normal mucous membranes (ID 31), maintenance of normal red blood cells (ID 32, 37), maintenance of normal skin (ID 33), maintenance of normal vision (ID 39), reduction of tiredness & fatigue (ID 41), protection of DNA, proteins & lipids from oxidative damage (ID 207) pursuant to Article 13(1) of Regulation (EC) No 1924/2006