Chemotherapy activates the DDR pathway
doi:10.3389/fnagi.2019.00257 Wu J, Jin Z, Zheng H, Yan LJ
It is widely studied for its potential to influence GnRH (Gonadotropin-Releasing Hormone) secretion , making it a key subject in research on fertility, reproductive hormone modulation, and endocrine function
The key effects are well-established: accelerated cell turnover (the outer layers of the stratum corneum, the skin's surface barrier, shed more quickly), direct stimulation of procollagen genes, and suppression of matrix metalloproteinases - the enzymes responsible for breaking down existing collagen
Cho YK, La Lee Y, Jung CH