This was a less common effect and not usually serious
Regardless of its origin, vitamin D undergoes two steps: first, in the liver, it is hydroxylated by 25-hydroxylase (CYP2R1) to form 25-hydroxyvitamin D [25(OH)D], and subsequently, in the kidney, it is hydroxylated by 1-hydroxylase (CYP27B1) to generate the biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)D] ( 1,25(OH)D exerts its effects by binding to the nuclear vitamin D receptor (VDR), forming a heterodimer with the retinoid X receptor (RXR), which then binds to vitamin D response elements (VDREs) on target genes
vitamin c mampu merangsang produksi kolagen sehingga dapat mencegah penuaan dini pada kulit agar tetap kencang dan mulus
Usually, people take about 400 to 500 g once a day
Wir haben aber beschlossen, diesen Begriff nicht weiter zu verwenden