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In certain embodiments the formulation or composition provides immediate release of at least one active pharmaceutical ingredient

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In the EPIC-SR trial, which included subjects who were infected with SARS-CoV-2 Delta (79%) or Omicron (19%) variants, PAXLOVID treatment was associated with a 1.05 log10 copies/mL greater median decline in viral RNA shedding levels in nasopharyngeal samples through Day 5, with similar declines observed in subjects infected with Delta or Omicron variants

Post-operatively the animals were housed individually in an American Accreditation for Laboratory Animal the water maze consisted of a circular tank painted black (diameter: 1.6 m