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Supplementary material The Supplementary material for this article can be found online at: References 1

Due to the highly amyloidogenic nature of endogenous human insulin, researchers took inspiration from the proline residues in rat insulin, which are highly homologous but not amyloidogenic (known to disrupt the secondary structure), and incorporated them into the human insulin sequence to develop Pramlintide

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Likewise, polyphenols or omega-3 fatty acid combinations with chemotherapy are studied for pharmacodynamic synergy by means of endpoints such as tumour volume reduction, progression-free survival and amelioration of chemotherapy-induced toxicity along with quality-of-life enhancement, keeping a close watch for antagonistic interactions or organ-specific adverse effects (234)

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