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The 1-MX dose administered to the rats was calculated using US Food and Drug Administration for human equivalence doses (HED), assuming a human weight of 60 kg [31]

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In recent years, with the increasing resolution of the ASCT2 3D structure, cysteine residue C467 is an important part of the composition of the ASCT2 substrate binding site, and residue C467 plays a key role in recognizing and binding glutamine [176]