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This intervention also enhanced dopaminergic transmission and motor function, with KD-fed mice performing better in the motor performance tests [34, 35]

Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila

TMAO activated the expression of the inflammatory mediator high mobility group box 1 (HMGB1), which stimulated multiple receptors such as toll-like receptor 4 (TLR4), thus mediating extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) and the NF-B signaling pathway (82)