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A 2021 review of NNMT as a metabolic target stated plainly that clinical trials targeting NNMT have not been reported until now (Liu 2021, PMID 34368359) [5], and that held into 2026

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Ask specific screening questions about pregnancy, lactation, and chronic conditions (pernicious anaemia, cardiac disease, hypertension) that may interact with parenteral B-12 therapy

Its a fascinating area of study, one that demands a meticulous approach to experimental design and, crucially, to the 5-Amino-1MQ dosage

Then, divide the dose you need by the concentration to get the volume