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Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial

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Although NGF infusion in the brain showed slight cognitive improvements in AD patients, long-term administration of NGF through ICV was associated with serious side effects, such as hyper-innervation of cerebral blood vessels [47], hypophagia [48] and neuropathic pain [46]

These would provide steady drug levels without weekly injection burden

It has also been shown that long-term exposure to stress triggers biological mechanisms, in particular related to the regulation of the inflammatory cascade, which plays a key role in autoimmune diseases