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Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models

In situations where the FOXO4 protein is bound to p53, there is a tentative observation that p53 is prevented from binding to DNA, inhibiting the process of apoptosis and allowing cells to avoid programmed death

Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites

Positive control= reaction containing mCherry under constitutive expression