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This approach involved an extensive in silico protocol (illustrated in Figures 2A, B, Supplementary Figures S1S6), that included database management, ligand clustering, RMSD calculations, induced-fit docking, molecular dynamics simulations, TRAPP physicochemical analyses ( FIGURE 2 We identified nine distinct inhibitor families, each associated with a predictive machine learning model, a ligand-based pharmacophore model, and an ensemble pharmacophore model derived from ligand-receptor complexes

In fact, it can also quietly progress for around 7 to 14 years before it becomes quite obvious

A., & Kharbanda, K