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The peptide influences both endothelial nitric oxide synthase (eNOS), which produces the beneficial, vasodilating form of nitric oxide, and inducible nitric oxide synthase (iNOS), which can produce excessive amounts that contribute to inflammation and tissue damage

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(5) Contributing to Hangovers: Dehydration is a significant contributor to hangover symptoms, which can include headaches, dizziness, and fatigue

475 It has been proposed that due to the high Zn II binding affinity to the primary site, only the auxiliary site would be filled with Fe II in vivo with the other bound by a noncognate metal, most likely Zn II