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For those without an absorption problem, research suggests that high-dose oral B12 supplements can be as effective as injections in raising and maintaining B12 levels

Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action

Those more likely to experience rough symptoms initially include: People with chronic inflammation or autoimmune disorders

The B12 is commonly used and prescribed medications are considered safe

Too little signal and cells barely respond