Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, LaFramboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z
These multifunctional conjugates were produced by ester chains that lyse when exposed to the mildly acid microenvironment of the arthritic synovial membrane
In contrast, intravenous glutathione raises serious safety concerns, including the risk of anaphylaxis and hepatotoxicity, compounded by the lack of standardized protocols and rigorous clinical studies
S-adenosylmethionine limitation induces p38 mitogen-activated protein kinase and triggers cell cycle arrest in G1
Compounds that influence growth-factor signaling warrant careful oversight, and unsupervised use, especially of products from unregulated sources, carries real risk