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Therapeutic target Nuclear receptor In M.tb infections, several nuclear receptor agonists have demonstrated encouraging results in enhancing host antimicrobial defense and autophagy

Other signs include dry, cracked skin that may bleed, thickened or pitted nails, and, in some cases, joint pain

The recent discovery of cuproptosisa copper-dependent form of regulated cell death (RCD)has provided a crucial mechanistic link between this imbalance and cardiomyocyte loss

Cell membrane fortification

[5] Phospholipase D catalyzes the hydrolysis of phosphatidylcholine to form phosphatidic acid (PA), releasing the soluble choline headgroup into the cytosol