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In the early stages of CKD, different markers such as AOPPs, MDA, and plasma F2-isoprotanes can already be detected

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Vacuolar import of GSSG may play a role in maintaining cytosolic glutathione redox status (Tommasini et al., 1993).Recent observations in Arabidopsis suggest that vacuolar accumulation of GSSG is a physiologically important part of the response to oxidative stress (Queval et al., 2011)

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