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-KG deficiency blocks AMPK translation As an energy sensor, AMPK inhibits fatty acid synthesis and promotes FAO and mitochondrial metabolism to supply malate and isocitrate for NADPH homeostasis 26

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10.1038/s41380-018-0110-9 [DOI] [PMC free article] [PubMed] [Google Scholar] Tsay HJ, Wang P, Wang SL, Ku HH (2000) Age-associated changes of superoxide dismutase and catalase activities in the rat brain