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Melanotan 1 (afamelanotide) is MC1R-preferential : it is comparatively focused on the pigmentation receptor, which is precisely why its clinically observed effects center on skin darkening and photoprotection rather than on sexual function or appetite

Hsieh M.J

This finding was not confirmed in the SAGhE study though a significant trend with longer follow-up (although no trend with GH dose) was observed [66]

Kevin Sheth: Dr Sheth reports investigator-initiated clinical research funding to Yale from Hyperfine, Inc, Biogen, and Bard