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Several neurotrophic factors (IGF1, BDNF, and Wnt3) exhibit the canonical role in multiple neurogenic processes as follows: Insulin-like growth factor 1 (IGF1) acts through at least two pathways to stimulate proliferation, neuronal differentiation, morphogenic development, and survival of newly born cells

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CRISPR-Cas9-mediated genome editing has successfully generated Brassica varieties with significantly increased glucoraphanin accumulation by modulating key genes in the pathway, including MYB28, AOP2, and BCAT4 (96, 107)

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