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Additionally, the loss of the transcription factor CBF in tumor cells disrupts zinc homeostasis pathways, further impairing their responsiveness to TNF-dependent cytotoxicity [329]

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Thus, while conventional COFs are metal-free by design, strategically engineered COFs may intentionally integrate metal ions to impart specific functionalities

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Acetyl-L-carnitine (ALCAR) is a bioavailable form of L-carnitine, an essential molecule for transporting fatty acids across mitochondrial membranes so they can be used for energy