Frontiers in Pharmacology, 16, 1551843
Additionally, 2-fucosyllactose exhibited the ability to inhibit M1 macrophages polarization, rejuvenate GM diversity, restore the populations of Bifidobacterium spp., Prevotellaceae , and Akkermansia spp., while simultaneously impeding the growth of Stenotrophomonas spp (156) ( Figure 4 , Table 4 )
Abbreviations GCLC: Glutamate cysteine ligase catalytic subunit GCLM: Glutamate cysteine ligase modifier subunit GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species C1q: Complement component 1q C3: Complement component 3 GSDMD: Gasdermin D GSDME: Gasdermin E DAM: Disease associated microglia DAA: Disease associated astrocyte Iba1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei HO1: Hemeoxygenase 1 CCL: CC Chemokine ligand CXCL: C-X-C motif ligand AD: Alzheimers disease App: Amyloid precursor protein A: Amyloid beta App : NL-G-F App knockin mouse NL-G-F References Guo, C., Sun, L., Chen, X
Al-Malki AL, Sayed AAR
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