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[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Lione A

Controlled human exposure studies have demonstrated that short-term exposure - up to 8 hours - causes lung function decrements such as reductions in forced expiratory volume in one second (FEV1), and the following respiratory symptoms: Cough Throat irritation Pain, burning, or discomfort in the chest when taking a deep breath Chest tightness, wheezing, or shortness of breath The effects are reversible, with improvement and recovery to baseline varying from a few hours to 48 hours after an elevated ozone exposure

IKK activation could phosphorylate NF-B inhibitors, leading to their degradation by the proteasome, which then activates and releases NF-B complexes into the nucleus to trigger the expression of target genes involved in cell proliferation and apoptosis, initiating downstream signaling pathways [108]