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In acute or emergency situations, this approach can be appropriate and necessary

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Because the normal intracellular concentrations of both G6P and NADP are lower than their respective Michaelis constant ( K m ) values, it is likely that these two substrates themselves are the main regulators of intracellular G6PD activity, together with NADPH

However, the efficacy of oral iron supplementation is often constrained by the iron regulatory system, which includes the ferromodulin-iron transporter protein, to mitigate the risk of iron overload