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2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis

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However, further studies are still needed to optimize its clinical application, including dosage form improvement, combination therapy strategies and long-term safety assessment

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All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections