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Indeed, thyroid dysfunction is the most frequent endocrine irAE and may affect up to 40% of patients receiving ICIs (Baraka et al

Nsc109028 769

10.1056/NEJMoa1509819 116 TeedeH

Kondo R, Sakamoto N, Harada K, Hashimoto H, Morisue R, Yanagihara K, et al

MAMs are essential for the regulation of the neuronal Ca 2+ concentration via the SERCA, the ER channels inositol 1,4,5-trisphosphate receptors, the glucose-regulated protein 75, the MCU, and the voltage-dependent anion channel (VDAC) [61]