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A General Timeline to Expect Week 12: Many people report the first noticeable change here is sleep falling asleep more easily or waking up feeling more rested

For others, these agents are not sufficiently effective

Blood tests allow providers to measure growth hormone activity and ensure treatment is working effectively without pushing hormone levels too high

In individuals with trisomy 21, intellectual disability that accompanies the condition can make it difficult to identify cognitive change, and decline in functional independence may be more helpful in identifying change or assigning an initial stage

doi: 10.1016/j.bcp.2025.116797 171