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Therefore, potential therapeutic targets for regulating ferroptosis by enzymes related to PUFA synthesis need to be studied further

Differences in the expression levels of SLC7A11 in different tumor tissues, and differences in the expression levels of SLC7A11 between different patients may also be closely related to the temporal, spatial, and individual heterogeneity of tumor tissues

Fibroblasts (CAFs) constitute the largest group of nonimmune cells in the TME, and there is increasing evidence that CAFs can regulate glutamine levels in the TME and thus generate energy to promote the tricarboxylic acid cycle (TCA) cycle and supply energy for cancer cell growth [12]

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Khan M, Cortes J, Qiao W, Alzubaidi M, Pierce S, Slack R, Ravandi F, Kantarjian H, Borthakur G