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Although MAPT mutations are not specifically associated with AD, tau tangles are a key hallmark of the disease, and in humans the number of neurofibrillary tangles correlates with cognitive decline and neurodegeneration better than A plaques (Giannakopoulos et al., 2003)

Critical mechanistic studies by Heffernan et al

Special Populations Post-Bariatric Surgery Patients : Individuals who have undergone bariatric surgery, such as Roux-en-Y gastric bypass, are at a higher risk of vitamin B12 deficiency due to malabsorption

doi: 10.1021/jm401705g 37 KorkmazBLamortASDomainRBeauvillainCGieldonAYildirimAOet al