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Open questions also include an unresolved debate in the peer-reviewed literature about the implications of BPC-157s pro-angiogenic activity for cancer-relevant signaling pathways, raised in a 2025 literature review and disputed by the original research group

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Indeed, a previous study showed that the injection of cytokines in C57BL mice resulted in an increase in hepatic SREBP2 and HMGCoAr expression (38)