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Earley CJ, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee PC, Allen R

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Clinically, AD is characterized by progressive cognitive decline and pathologically, its two main hallmarks are intracellular neurofibrillary tangles comprised of the protein tau and extracellular -amyloid (A) plaques (Roy et al., 2023), since A aggregation has been determined as source of oxidative stress (Karapetyan et al., 2022) and oxidative stress has been shown to increase the aggregation of A (Mandal et al., 2022)