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Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation

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While it may seem to contradict previous reports demonstrating the ability for IH to expand the early progenitor populations 18,38 , it is important to recognize that these previous studies used thirty or more days of IH