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Peer review Peer review information Communications Biology thanks Yoshitaka Isaka and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Five PK studies all reported that children under 12 years of age metabolise paracetamol predominately by sulphation compared with adults ( n = 114 children in total) and that the adult pattern of metabolism is present beyond the age of 12 [44,45,46,47,48]

Commercial features of placebo and therapeutic efficacy

On average, they may cost between $100-300 per session

Only lyophilized (powder) peptides tolerate freezing in published stability data reconstituted vials are refrigerated, not frozen